Carisoprodol (trade names embody Soma, Somadril, Carisoma, Carisoprodol Watson, Listaflex, Somacid, Vanadom) is a muscle relaxant from carbamic acid esters pharmacological group. This treatment is indicated together with relaxation and bodily remedy to relieve musculoskeletal pain, skeletal muscle spasms, stiffness, muscle injuries, pressure, sprain, acute back pain, discomfort associated with short-term, painful musculoskeletal situations, and for other medical purposes. It can also be widely off-label used as leisure drug. Carisoprodol could also be prescribed alone for monotherapy or in combinations with other medicine, similar to psycholeptics.

Clinical presentation </h2

Overdosage of Carisoprodol (Soma) tablets commonly produces CNS depression. Death, coma, respiratory melancholy, hypotension, seizures, delirium, hallucinations, dystonic reactions, nystagmus, blurred vision, mydriasis, euphoria, muscular incoordination, rigidity, and/or headache have been reported with Soma overdosage. Serotonin syndrome has been reported with carisoprodol intoxication. Many of the carisoprodol overdoses have occurred within the setting of multiple drug overdoses (including medicine of abuse, illegal medicine, and alcohol). The effects of an overdose of this treatment and different CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) can be additive even when one of many medication has been taken within the beneficial dosage. Fatal unintended and non-accidental overdoses of SOMA have been reported alone or in combination with CNS depressants.

Treatment of overdosage

Basic life help measures should be instituted as dictated by the scientific presentation of the Soma overdose. Vomiting should not be induced because of the danger of CNS and respiratory melancholy, and subsequent aspiration. Circulatory assist must be administered with volume infusion and vasopressor agents if needed. Seizures ought to be treated with intravenous benzodiazepines and the reoccurrence of seizures may be handled with phenobarbital. In instances of extreme CNS depression, airway protecting reflexes may be compromised and tracheal intubation should be thought-about for airway safety and respiratory support.

For decontamination in circumstances of severe toxicity, activated charcoal should be thought-about in a hospital setting in patients with large overdoses who present early and aren’t demonstrating CNS melancholy and might protect their airway.